Olanzapine for the Treatment of Psychosis in Patients With Parkinsons Disease and Dementia
Identifieur interne : 000222 ( Main/Exploration ); précédent : 000221; suivant : 000223Olanzapine for the Treatment of Psychosis in Patients With Parkinsons Disease and Dementia
Auteurs : Laura Marsh [États-Unis] ; Constantine Lyketsos [États-Unis] ; Stephen G. Reich [États-Unis]Source :
- Psychosomatics [ 0033-3182 ] ; 2001.
Abstract
Psychotic symptoms are a common complication in Parkinsons disease with dementia. The authors conducted an open-label 6-week trial of olanzapine preceded by a placebo lead-in in five subjects with Parkinsons disease, mild to moderately severe dementia, and psychosis. Four of the subjects terminated the trial early because of worsening motor function, sedation, or paranoia. There was no improvement in psychotic symptoms, and functional abilities declined significantly. Olanzapine appears to be poorly tolerated in patients with Parkinsons disease, psychotic symptoms, and dementia.
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DOI: 10.1176/appi.psy.42.6.477
Affiliations:
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Reich</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:F7524C782E5194C3851FAFC6DC9A9B0EB916ED3F</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1176/appi.psy.42.6.477</idno><idno type="url">https://api.istex.fr/document/F7524C782E5194C3851FAFC6DC9A9B0EB916ED3F/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002685</idno><idno type="wicri:Area/Main/Curation">002345</idno><idno type="wicri:Area/Main/Exploration">000222</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Olanzapine for the Treatment of Psychosis in Patients With Parkinsons Disease and Dementia</title><author><name sortKey="Marsh, Laura" sort="Marsh, Laura" uniqKey="Marsh L" first="Laura" last="Marsh">Laura Marsh</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Morris K. Udall Parkinsons Disease Research Center of Excellence at Johns Hopkins, the Neuropsychiatry Service, Department of Psychiatry and Behavioral Sciences, Baltimore, MDMovement Disorders Center, Department of Neurology, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Lyketsos, Constantine" sort="Lyketsos, Constantine" uniqKey="Lyketsos C" first="Constantine" last="Lyketsos">Constantine Lyketsos</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Morris K. Udall Parkinsons Disease Research Center of Excellence at Johns Hopkins, the Neuropsychiatry Service, Department of Psychiatry and Behavioral Sciences, Baltimore, MDMovement Disorders Center, Department of Neurology, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Reich, Stephen G" sort="Reich, Stephen G" uniqKey="Reich S" first="Stephen G." last="Reich">Stephen G. Reich</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Morris K. Udall Parkinsons Disease Research Center of Excellence at Johns Hopkins, the Neuropsychiatry Service, Department of Psychiatry and Behavioral Sciences, Baltimore, MDMovement Disorders Center, Department of Neurology, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Psychosomatics</title><title level="j" type="abbrev">PSYM</title><idno type="ISSN">0033-3182</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2001">2001</date><biblScope unit="volume">42</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="477">477</biblScope><biblScope unit="page" to="481">481</biblScope></imprint><idno type="ISSN">0033-3182</idno></series><idno type="istex">F7524C782E5194C3851FAFC6DC9A9B0EB916ED3F</idno><idno type="DOI">10.1176/appi.psy.42.6.477</idno><idno type="PII">S0033-3182(01)70454-9</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0033-3182</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Psychotic symptoms are a common complication in Parkinsons disease with dementia. The authors conducted an open-label 6-week trial of olanzapine preceded by a placebo lead-in in five subjects with Parkinsons disease, mild to moderately severe dementia, and psychosis. Four of the subjects terminated the trial early because of worsening motor function, sedation, or paranoia. There was no improvement in psychotic symptoms, and functional abilities declined significantly. Olanzapine appears to be poorly tolerated in patients with Parkinsons disease, psychotic symptoms, and dementia.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Marsh, Laura" sort="Marsh, Laura" uniqKey="Marsh L" first="Laura" last="Marsh">Laura Marsh</name></region><name sortKey="Lyketsos, Constantine" sort="Lyketsos, Constantine" uniqKey="Lyketsos C" first="Constantine" last="Lyketsos">Constantine Lyketsos</name><name sortKey="Reich, Stephen G" sort="Reich, Stephen G" uniqKey="Reich S" first="Stephen G." last="Reich">Stephen G. Reich</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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